Krebs cycle

or Link reaction . The reaction of pyruvate oxidation is 2x CH COCOOH 2NAD 2CoA 2xCH CO.CoA 2NADH 2H 2CO ↑ Pyruvate dehydrogenase complex consist of three distinct enzymes, such as . Pyruvate dehydrogenase . Dihydrolipoyil transacetylase .

Dihydrolipoyil dehydrogenase and five different coenzymes, TPP (Thymine Pyro Phosphate), NAD , FAD, CoA and lipoate . . . Krebs cycle or Citric acid cycle or TCA cycle: Two molecules of acetyl CoA formed from link reaction now enter into Krebs cycle.

It is named after its discoverer, German Biochemist Sir Hans Adolf Krebs ( ). The enzymes necessary for TCA cycle are found in mitochondrial matrix except succinate dehydrogenase enzyme which is found in mitochondrial inner membrane (Figure . ). Pyruvate dehydrogenase complex/ Mg