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5.10 Genetic Code

Chapter 5: CHAPTER 5 · BIO ZOOLOGY

. Genetic Code DNA is the genetic material that carries genetic information in a cell and from generation to generation. At this stage, an attempt will be made to determine in what manner the genetic information exists in DNA molecule? Are they written in coded language on a DNA molecule?

If they occur in the Fig. . Process of transcription in eukaryotes Capping ' ' ' ' ' ' Exon Cap m G ppp ' m G ppp ' m G ppp ' m G ppp ' ' Intron RNA splicing Polyadenylation Poly A tail Messenger RNA (m RNA) m RNA XII Std Biology-Zoology Chapter- XII Std Biology-Zoology Chapter- Molecular Genetics 6HFRQG1XFOHRWLGHLQ&RGRQ & $ * )LUVWQXFOHRWLGHLQFRGRQ ¶HQG & $ * & $ * & $ * & $ * & $ * 7KLUGQXFOHRWLGHLQFRGRQ ¶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able . Genetic code dictionary Marshall Nirenberg , Severo Ochoa (enzyme polynucleotide phosphorylase called Ochoa’s enzyme), Hargobind Khorana , Francis Crick and many others have contributed significantly to decipher the genetic code.

The order in which bases are arranged in mRNA decides the order in which amino acids are arranged in proteins. Finally a checker board for genetic code was prepared ( table . ). The salient features of genetic code are as follows: • The genetic codon is a triplet code and codons code for amino acids and codons do not code for any amino acid and function as stop codon ( Termination ) .

• The genetic code is universal. It means that all known living systems use nucleic acids and the same three base codons (triplet codon) direct the synthesis

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