Fig. 10.2 Production of recombinant HB Vaccine

Fig. . Production of recombinant HB Vaccine The recombinant vaccine for hepatitis B (HbsAg) was the first synthetic vaccine launched in which was marketed by trade names Recombivax and Engerix-B. India is the fourth country in the world after USA, France and Belgium to develop an indigenous hepatitis B vaccine. Applications of Biotechnology have no effective treatment and so gene therapy could offer hope for many people. There are two strategies involved in gene therapy namely; Gene augmentation therapy which involves insertion of DNA into the genome to replace the missing gene product and Gene inhibition therapy which involves insertion of the anti sense gene which inhibits the expression of the dominant gene (Fig. . ) . The two approaches to achieve gene therapy are somatic cell and germ line gene therapy . Somatic cell therapy involves the insertion of a fully functional and expressible gene into a target somatic cell to correct a genetic disease permanently whereas Germline gene therapy