metabolic conditions Maturity Onset Diabetes of the Young (MODY) is a relatively rare type of Type Diabetes that is characterized by an early age of onset (age - ) and autosomal dominant inheritance. Unlike type Diabetes, often associated with insulin resistance, MODY is caused by a primary defect in pancreatic beta cell function resulting in decreased insulin secretion. Patients with MODY are not usually obese. .
. Causes Primary or Idiopathic diabetes Heredity: There is a familial tendency to develop Diabetes. If both parents are diabetic, all their children will be diabetic. If one parent is s diabetic, and the other is a diabetic carrier, half of their children will be potential diabetics.
If one parent is diabetic and the other a non diabetic and also a non carrier, none of their children will be diabetic, but they all will be carriers. However, environmental and other factors play a role in unmasking an underlying diabetes genotype and whether a person with a genetic predisposition actually develops the disease or not. UNIT - - DIET IN DIABETES MELLITUS Age: The disease may occur at any age but about % of the cases occur after the age of . Sex: In the younger age groups, diabetes is more commonly seen in males than in females.
In middle age, women are more affected and the chances increase with pregnancy and increasing parity. Obesity: There is a strong association between diabetes and obesity. In obesity, there is hyperinsulinaemia and insulin resistance or impaired insulin uptake by receptors in target tissues. Obese people are also less physically active than normal weight individuals which increase the risk of diabetes.
Why weight is a risk factor for Diabetes? Overweight people have fewer available insulin receptors. More fat requires more insulin, promoting insulin resistance. Fat cells release free fatty acids which interfere with glucose metabolism.
Dietary factors/Nutritional factors: A high intake of sugar has also been related to obesity and may predispose to diabetes. A low intake of fibre due to consumption of refined foods is associated with high prevalence of