(refer Unit , Class XII). . Acylation Aliphatic and aromatic primary and secondary amines react with acid chlorides, anhydrides and esters by nucleophilic substitution reaction. This reaction is known as acylation.
You can consider this reaction as the replacement of hydrogen atom of –NH or > N–H group by the acyl group. The products obtained by acylation reaction are known as amides. The reaction is carried out in the presence of a base stronger than the amine, like pyridine, which removes HCl so formed and shifts the equilibrium to the right hand side. Amines also react with benzoyl chloride (C H COCl).
This reaction is known as benzoylation. Methanamine Benzoyl chloride Methylbenzamide NH C C CH CH H l NH l What do you think is the product of the reaction of amines with carboxylic acids ? They form salts with amines at room temperature. Arrange the following in decreasing order of their basic strength: C H NH , C H NH , (C H ) NH , NH The decreasing order of basic strength of the above amines and ammonia follows the following order: (C H ) NH > C H NH > NH > C H NH